Endocrine Abstracts

Background: IGF1 is mainly produced in the liver and it induces beneficial effects on many systems. However, the role of IGF1 on the liver itself is poorly understood, probably due to the fact that healthy hepatocytes barely express IGF1 receptors. Previous works in our group showed that IGF1 supplementation induces beneficial actions in cirrhosis, inducing a relevant histological improvement, reducing fibrosis1. Based on these data the aim of this work was to inqui...

Background: IGF1 is mainly produced in the liver and it induces beneficial effects on many systems. However, the role of IGF1 on the own liver is poorly understood, probably due to the fact that healthy hepatocytes barely express IGF1 receptors. Previous works in our group showed that IGF1 supplementation induces beneficial actions in cirrhosis, including antioxidant, anti-inflammatory and antifibrogenic effects. Based on these data the aim of this work was to deep into the me...